While immotile cilia can result in bronchiectasis, this does not represent a frequent cause.
This describes alpha 1 antitrypsin deficiency, which is the cause of panacinar emphysema. Panacinar emphysema is accelerated by cigarette smoking, and results in diffuse small air sac dilatations, not proximal airway dilatation.
Mutations in TSC1 and TSC2 are the cause of tuberous sclerosis. Tuberous sclerosis can involve the lung in the form of lymphangioleiomyomatosis, causing cystic changes and fibrosis, not bronchiectasis. Angiomyolipomas can be seen in adipose tissue around bronchi, and micronodular pneumocyte hyperplasia can occur in tuberous sclerosis as well.
Mutations in folliculin (FLCN) have been associated with the Birt-Hogg-Dube syndrome, an autosomal dominant disease that causes skin, kidney, and lung manifestations. Pulmonary manifestations are lung cysts, usually basally located.
The process depicted is bronchiectasis, with diffuse airway dilatation and mucopurulent secretion. Bronchiectasis can have many causes, and cystic fibrosis is a common cause of bronchiectasis.
