While resistance mutations do exist (and are generally acquired after therapy) the primary goal of mutation testing is to identify mutations that predict response, not resistance.
This is true. This oncogenic activation is thought to make tumor cells dependent on this pathway, and, therefore, blocking this “addiction” to growth signals causes tumor regression.
Although this number appears to vary by population, in the United States the rate of EGFR mutation positive lung adenocarcinoma is closer to 20%.
While EGFR mutations are associated with female gender, younger age and nonsmoking status these parameters are not sufficient to triage cases for testing. In addition, while nonmucinous lepidic and papillary growth patterns have also been associated with mutation, this association is also not strong enough to triage cases for testing.
Overall, these alterations are mutually exclusive.