Clinical Pathology: General Principles, Lab Management, Clinical Chemistry

39a) Use this figure to answer the following four questions. Which letter best represents the test result cutoff value that would yield the highest sensitivity?

• Sensitivity is the proportion of diseased individuals with a positive test result.

• Specificity refers to the proportion of nondiseased individuals who have a negative test result.

• Specificity (%) = 100 × .

• Generally speaking, a test with high specificity has a high positive predictive value; that is, a positive test result rules-in the diagnosis.

• Sensitivity (%) = 100 × .

Scott A, Greenberg PB, Poole PJ: Cautionary tales in the clinical interpretation of studies of diagnostic tests. Intern Med J 2008;38:120–129.

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