Elsevier Pathology

Clinical Pathology: General Principles, Lab Management, Clinical Chemistry

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39a) Use this figure to answer the following four questions. Which letter best represents the test result cutoff value that would yield the highest sensitivity?

• Sensitivity is the proportion of diseased individuals with a positive test result.

• Specificity refers to the proportion of nondiseased individuals who have a negative test result.

• Specificity (%) = 100 × .

• Generally speaking, a test with high specificity has a high positive predictive value; that is, a positive test result rules-in the diagnosis.

• Sensitivity (%) = 100 × .

Scott A, Greenberg PB, Poole PJ: Cautionary tales in the clinical interpretation of studies of diagnostic tests. Intern Med J 2008;38:120–129.

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