Therefore, answer A is correct. Finally, while viral infections can lead to pleural opacity and fibrosis, the diffuse thickening in the gross photograph exceeds what is expected from viral infections.
Pleural plaques usually involve parietal pleura, and the image shows visceral pleural thickening; pleural plaques are usually white and shiny. In addition, even large pleural plaques do not have the continuous circumferential appearance seen in this gross picture.
A typical immunohistochemistry profile for malignant mesothelioma includes positive calretinin, WT-1, and cytokeratin 5/6; these tumors are negative for B72.3, BerEP4, LeuM1 (CD15), and CEA.
The profile in choice B is that of squamous carcinoma; positive p63 and negative calretinin and WT-1 is unusual for malignant mesothelioma. A pattern of pleural growth is unusual for squamous carcinoma.
Electron microscopy can be useful in the diagnosis of malignant mesothelioma; the distinctive feature is long slender microvilli; short microvilli are characteristic of adenocarcinoma.