Clinical Pathology: Clinical Chemistry

• Fecal elastase is stable during transit through the bowel.

• Fecal elastase is concentrated in well-formed stools by fourfold to fivefold.

• The test is adequate for the diagnosis of severe pancreatic insufficiency but loses sensitivity in the setting of milder deficiencies.

• Fecal elastase is a better biomarker for pancreatic insufficiency than other pancreatic enzymes in stool.

• This biomarker is not affected by exogenous oral enzyme replacement.

Wiwanitkit V: Faecal elastase-1 (EL-1) in pediatric patients with cystic fibrosis. J Pediatr (Rio J) 2011;87(3):273.

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