Blastic plasmacytoid dendritic cell leukemia essentially has the same immunophenotype as normal plasmacytoid dendritic cells (CD4 positive, CD123 positive), but with the additional aberrant expression of CD56 and TdT.
Aggressive NK-cell leukemia has the following immunophenotype: CD2 positive, surface CD3 negative, CD4 negative, CD5 negative, CD8 positive/negative, CD34 negative, CD56 positive, TdT negative, and EBV positive.
Hepatosplenic T-cell lymphoma has the following immunophenotype: CD2 positive, CD3 positive, CD4 negative, CD5 negative, CD8 negative/positive, CD19 negative, CD34 negative, CD56 positive/negative, TdT negative, and EBV negative.
Plasma cell leukemia has the following immunophenotype: CD2 negative, CD3 negative, CD4 negative, CD5 negative, CD8 negative, CD19 negative, CD34 negative, CD56 positive/negative, TdT negative, and EBV negative. In addition, the cells are CD138 positive, CD38 positive (bright), CD79a positive, and CD20 negative/positive.
Extranodal NK/T-cell lymphoma has the following immunophenotype: CD2 positive, surface CD3 negative, CD4 negative, CD5 negative, CD8 positive/negative, CD19 negative, CD34 negative, CD56 positive, TdT negative, and EBV positive.
