Diagnosis:
Papillary thyroid carcinoma
• The nuclear features of papillary thyroid carcinoma include enlargement, irregular contours, chromatin dispersion/nuclear clearing, grooves, and pseudoinclusions containing cytoplasmic material.
• Nuclear grooves sometimes occur in nonneoplastic contexts. In the thyroid, the nuclei of oncocytes can show grooves.
• Many other tumors characteristically demonstrate nuclear grooves. Grooved nuclei are typical of solid pseudopapillary tumor of the pancreas, and they represent a diagnostic feature of chondroblastoma.
• Among ovarian tumors, Brenner tumor and the adult type of granulosa cell tumor display nuclear grooves.
• Bronchioloalveolar carcinoma/pulmonary adenocarcinoma in situ sometimes shows nuclear pseudoinclusions and grooves. These features may be useful in terms of distinguishing this lesion from benign reactive atypia.
Atkins KA::
The diagnosis of bronchioloalveolar carcinoma by cytologic means. Am J Clin Pathol 2004;122:14-16.
LiVolsi VA:
Papillary thyroid carcinoma: an update. Mod Pathol 2011;24:S1-S9.
LiVolsi VA, Albores-Saavedra J, Asa SL, et al: Papillary carcinoma.In DeLellis RA, Lloyd RV, Heitz PU, Eng C (eds):
Pathology and Genetics of Tumours of Endocrine Organs. World Health Organization Classification of Tumours. Lyon: IARC Press, 2004, pp 57-66.
