Diagnosis: rearrangement
• p190 is the most common protein isoform seen in acute B-lymphoblastic leukemia (B-ALL) patients with bcr-abl rearrangement.
• p190 is the most common isoform seen in pediatric B-ALL patients. In contrast, in adult B-ALL patients (much less common than in pediatric B-ALL), about half of patients have the p190 isoform and the other half have the p210 isoform.
• p16 (A) is a tumor suppressor gene and is not a protein encoded by the bcr-abl rearrangement. In acute lymphoblastic leukemia p16 can show homozygous deletion and is associated with a poor prognosis.
• p210 (C) is the most common protein isoform seen in chronic myeloid leukemia. p230 (D) is the second most common protein isoform seen in chronic myeloid leukemia (CML). The p230 isoform is associated with a prominent neutrophil maturation in CML.
• p53 (E) is a tumor suppressor gene and is not a protein encoded by the bcr-abl rearrangement. p53 mutation is associated with a poor prognosis in many malignancies, including hematolymphoid malignancies.
