Diagnosis: Enzyme deficiencies in hereditary erythrocyte disorders
• Pyruvate kinase is the most common hereditary erythrocyte enzyme deficiency in the glycolytic pathway and accounts for up to 90% of cases.
• Hexokinase (B), aldolase (C), and phosphofructokinase (E) deficiencies are extremely rare.
• Glucose-6-phosphate dehydrogenase is not an enzyme of the glycolytic pathway, but of the pentose phosphate pathway (hexose monophosphate shunt) (A).
