Anatomic Pathology: Infectious Disease Pathology

1015) A 40-year-old man with dyspepsia underwent gastroscopy and gastric biopsy. The biopsy diagnosis resulted in triple antibiotic therapy, and his symptoms resolved. Which of the following statements about this infection is FALSE?

H. heilmannii differs from H. pylori in bacterial size, shape, and number. H. heilmannii is larger, spiral rather than curved, and present in significantly smaller numbers, mainly in foveolar lumina, where it aggregates in clusters or stacks.

H. heilmannii does not adhere to the epithelial cell surface, as does H. pylori.

• Evidence suggests that a unique lymphocytic pattern of inflammation, with the propensity to involve the foveolar lumen, is a distinctive histopathologic aspect of H. heilmannii chronic gastritis.

• Symptoms, treatment, and complications are identical to those of H. pylori gastritis.

• Immunohistochemical staining specific for H. pylori also reacts with H. heilmannii, indicating cross-reacting antigenic epitopes between both organisms.

Andersen LP: New Helicobacter species in humans. Dig Dis 2001;19(2):112-115.

Singhal AV, Sepulveda AR: Helicobacter heilmannii gastritis: a case study with review of literature. Am J Surg Pathol 2005;29(11):1537-1539.

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