Anatomic Pathology: Forensic Pathology

1198) All of the following statements about this finding are correct EXCEPT:

• There are numerous risk factors for deep venous thrombosis and resultant pulmonary embolism.

• Strong risk factors for deep venous thrombosis include lower extremity fractures, major general surgery (especially lower extremity orthopedic operations), and spinal cord injury.

• Moderate risk factors include hormonal therapy, paralytic stroke, malignancy, chemotherapy, history of venous thrombosis, congestive heart failure etiologies, and postpartum period.

• Weak risk factors include inactivity owing to prolonged sitting, obesity, varicose veins, and peripartum period.

• Virchow described three risk factors for thrombosis that are known as Virchow triad—endothelial injury, stasis, and hypercoagulability.

• With the advent of genetic tests, heritable thrombophilias may be definitively diagnosed.

• For deaths resulting from pulmonary embolism, postmortem blood samples may be analyzed for mutations in factor V Leiden and prothrombin, the most common causes of thrombophilic coagulation disorders.

• The mortality rate of patients with acute untreated pulmonary embolism is 30% to 35%.

Andrew TA, Fairweather R: Prothrombin G20210A mutation and sudden death. Am J Forensic Med Pathol 2003;24(4):377-380.

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