Anatomic Pathology: Immunopathology

1250) This is a lesion of the uterine cervix in a 24-year-old patient with lesional cells strongly positive for p16ink4a. Which statement regarding anti-p16ink4a staining and cervical dysplasia is INCORRRECT?

• Between 40% to 70% of low grade cervical dysplasia cases show strong staining for p16ink4a, which decreases its value as biomarker to distinguish between low grade and high grade dysplasia.

• It has been suggested, however, that strongly p16ink4a positive low grade lesions have a higher tendency to progress to high grade dysplasia.

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