Clinical Pathology: General Principles, Lab Management, Clinical Chemistry, Microbiology, Immunology & Histocompatibility, Urinalysis, Body Fluids, Clinical Microscopy

Helicobacter pylori grows at 37° C. In addition, it is oxidase, catalase, and urease positive. On susceptibility testing, it is resistant to nalidixic acid and sensitive to cephalothin.

• Warthin-Starry and Giemsa stains of tissue biopsies are alternatives to immunohistochemistry for the identification of H. pylori.

• Always consider nonsteroidal antiinflammatory drug (NSAID) use as a cause of peptic ulcer disease.

H. pylori should be excluded before initiating PPI and antibiotic therapy because treatment can obscure the diagnosis, causing false-negative results if subsequent diagnostic tests are conducted. In practice, PPI therapy is often initiated before confirmation.

• A low bacterial load in general, even without treatment, can yield false-negative test results.



 
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