The presence of anemia is a minor criterion in making the diagnosis of primary myelofibrosis (PMF). The major criteria to make this diagnosis are (1) megakaryocytic proliferation and atypia, (2) not meeting World Health Organization (WHO) criteria for other myeloid neoplasms, and (3) clonal molecular change or, in the absence of a marker of clonality, exclusion of other causes of fibrosis.
The presence of bone marrow fibrosis is a nonspecific finding and by itself is not a major criterion in making the diagnosis of PMF. The major criteria to make this diagnosis are (1) megakaryocytic proliferation and atypia, (2) not meeting WHO criteria for other myeloid neoplasms, and (3) clonal molecular change or in the absence of a marker of clonality, exclusion of other causes of fibrosis.
Presence of increased blast count is not related to the diagnosis of PMF. It is useful in stratifying myelodysplastic syndromes (MDSs) and making a diagnosis of acute leukemia. The major criteria to make this diagnosis are (1) megakaryocytic proliferation and atypia, (2) not meeting WHO criteria for other myeloid neoplasms, and (3) clonal molecular change or in the absence of a marker of clonality, exclusion of other causes of fibrosis.
The presence of a clonal molecular alteration is a major criterion to make the diagnosis of PMF. The other major criteria are (1) megakaryocytic proliferation and atypia, and (2) not meeting WHO criteria for other myeloid neoplasms.
The presence of splenomegaly is a minor criterion in making the diagnosis of PMF. The major criteria to make this diagnosis are (1) megakaryocytic proliferation and atypia, (2) not meeting WHO criteria for other myeloid neoplasms, and (3) clonal molecular change or in the absence of a marker of clonality, exclusion of other causes of fibrosis.
