Anatomic Pathology: Genitourinary Pathology

• Klinefelter syndrome patients are characterized by tall habitus, abnormal body proportions, and small and firm testes. They have a decrease in pubic and facial hair and a large percentage have gynecomastia.

• They have decreased spermatogenesis, can either be azoospermic or oligospermic, and frequently have problems of infertility.

• The histologic changes in the testes of Klinefelter syndrome patients include tubular hyalinization, a decrease or absence of germ cells in nonhyalinized tubules when present, and Leydig cell hyperplasia.

Wikström AM, Dunkel L: Klinefelter syndrome. Best Pract Res Clin Endocrinol Metab 2011;25(2):239-250.

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