Diagnosis: Hashimoto thyroiditis
• Several studies have demonstrated immune complex deposition within the context of Hashimoto thyroiditis./p>
• Laboratory work-up of patients with Hashimoto thyroiditis may reveal antithyroglobulin, antithyroid peroxidase, and antimicrosomal antibodies.
• These autoantibodies likely mediate thyrocyte dysfunction as follows: deposition of immune complexes (as immune complexes) on the basement membranes of follicular epithelial cells leads to complement activation and thyrocyte necrosis.
• Hashimoto thyroiditis is associated with several human leukocyte antigen (HLA) alleles including HLA-DR3, HLA-DR4, and HLA-DR5.
• The incidence of Hashimoto thyroiditis is increased among individuals with Turner syndrome and Down syndrome.
